Bilateral Cortical Necrosis of Kidneys in Cortisone-Treated Rabbits Following Injection of Bacterial Toxins.

Abstract

Summary 1. Bilateral cortical necrosis of the kidneys was observed in rabbits which were treated with large doses of cortisone and then given a single intravenous injection of meningococcal or S. marcescens (P-25) toxin. This lesion did not occur when animals were given injections of cortisone alone, or toxin alone. 2. A similar renal lesion occurred in cortisone-treated Syrian Hamsters following an intraperitoneal injection of P-25 toxin.