Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
- 1 August 1981
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 10 (2), 122-126
- https://doi.org/10.1002/ana.410100203
Abstract
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.Keywords
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