Quantitative trait loci analysis affecting contextual conditioning in mice
- 1 November 1997
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 17 (3), 335-337
- https://doi.org/10.1038/ng1197-335
Abstract
In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.Keywords
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