Bernstein's and gene‐counting methods in generalized ABO‐like systems
- 1 January 1976
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 39 (3), 361-373
- https://doi.org/10.1111/j.1469-1809.1976.tb00141.x
Abstract
Although the simple and adjusted Bernstein's methods are fully efficient for m=2 and m=3 (ABO system) respectively, their efficiency declines for larger values of m. For m greater than or equal to 4, the adjusted or modified Bernstein's method with a single counting iteration leads to a nearly efficient estimator. A single degree of freedom chi-square test of the Hardy-Weinberg law for all m is derived. Some findings on the statistical efficiency of typing various numbers of antigens are given. All the results are illustrated in numerical examples.Keywords
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