Mechanical Activation of Pharmaceutical Systems
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 02 (6), 302-306
- https://doi.org/10.1023/A:1016397719020
Abstract
Mechanical activation has become a phenomenon of general significance in pharmaceutics. This report describes the extent of activation induced by relevant processes. With the use of the Eyring equation the transformation of structurally stored energy into chemical energy and the implied free enthalpy as well as the excess free enthalpy (activity) were evaluated from the rate of an indicator reaction. A comparison was made between different kinds of milling and tabletting with respect to pharmaceutical conditions. An optimization of these processes was derived.Keywords
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