How do some haemophiliacs develop inhibitors?
- 1 July 1998
- journal article
- review article
- Published by Wiley in Haemophilia
- Vol. 4 (4), 538-542
- https://doi.org/10.1046/j.1365-2516.1998.440538.x
Abstract
Summary. The purpose of this presentation is to concentrate on three issues: Is there an explanation for the large difference in reported incidence rates of inhibitor formation in haemophiliacs? Why do not all severe patients develop inhibitors? And how on the contrary do some patients with mild haemophilia develop inhibitors?Keywords
This publication has 31 references indexed in Scilit:
- Factor VIII immunogenicityHaemophilia, 1998
- Dominant C2 Domain Epitope Specificity of Inhibitor Antibodies Elicited by a Heat Pasteurized Product, Factor VIII CPS-P, in Previously Treated Hemophilia A Patients without InhibitorsThrombosis and Haemostasis, 1998
- Absence of Inhibitors in Previously Untreated Patients with Severe Haemophilia A after Exposure to a Single Intermediate Purity Factor VIII ProductThrombosis and Haemostasis, 1997
- Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII InhibitionPublished by Elsevier ,1996
- Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A.Journal of Clinical Investigation, 1996
- Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies.Journal of Clinical Investigation, 1994
- Review of the Hepatitis A Epidemics in Hemophiliacs in EuropeVox Sanguinis, 1994
- Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIIIThe Lancet, 1993
- Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals.Proceedings of the National Academy of Sciences, 1992
- Incidence of development of factor VIII and factor IX inhibitors in haemophiliacsThe Lancet, 1992