Leukocyte Engagement of Platelet Glycoprotein Ibα via the Integrin Mac-1 Is Critical for the Biological Response to Vascular Injury
- 8 November 2005
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 112 (19), 2993-3000
- https://doi.org/10.1161/circulationaha.105.571315
Abstract
Background— Leukocyte-platelet interactions are critical in the initiation and progression of atherosclerosis as well as restenosis. Although the leukocyte integrin Mac-1 (αMβ2, CD11b/CD18) has been implicated in the firm adhesion and transmigration of leukocytes at sites of platelet deposition, the precise αMβ2 counterligand responsible for mediating adhesion-strengthening interactions between neutrophils and platelets in vivo has not previously been identified.Keywords
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