Hereditary Adult-Onset Leukodystrophy Simulating Chronic Progressive Multiple Sclerosis

Abstract

We studied a large kindred with a chronic progressive neurologic disorder affecting at least 10 men and 11 women in four generations in a pattern compatible with autosomal dominant inheritance. In 20 of the affected subjects, evaluated before the availability of computerized tomography and without regard to family history, the diagnosis was multiple sclerosis.