Exploring prokaryotic diversity in the genomic era
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Open Access
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Genome Biology
Abstract
Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples.Keywords
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