Gastric secretion during pregnancy and lactation in the rat

Abstract

Gastric acid secretion has been studied in the rat before, during and after pregnancy using different types of stomach preparation. During the same periods the histamine-forming capacity (HFC) has been determined in gastric mucosa and mammary gland. In rats with a whole stomach fistula interdigestive acid secretion is increased during pregnancy and lactation. In rats with a denervated chronic pouch secretory response to stimulation with gastrin and histamine is augmented during pregnancy and lactation. The histamine forming capacity (HFC) of the gastric mucosa is increased 2-3 times during the last days of pregnancy and also during lactation. The HFC of the mammary gland is increased 2-3 times during lactation as compared with the fully developed gland in pregnancy.