Four examples of diffuse eosinophilic gastroenteritis are reported to demonstrate roentgenographically the abnormalities which may be produced by eosinophilic infiltration of the stomach and small bowel. The nodular contour defects produced by dense eosinophilic infiltration of mucosa and submucosa are often sharply defined. Involvement of the muscularis, serosa, and mesentery results in separation of the bowel loops. Gastric involvement is often accompanied by small bowel disease. The roentgenographic features are completely reversible as a result of systemic steroid therapy.