Abstract
A patient with diabetes and Addison''s disease, observed for 5 yrs., showed a progressive hypothyroidism. The details of the case are reviewed. It seems unlikely that the changes described are due to a panhypopituitarism. Comparison of the effects of testosterone propionate in this patient and in a patient with intact adrenals indicates that intact adrenals are not necessary or stimulating to the action of testosterone. In the patient reported testosterone caused glycosuria and gly-cemia as well as the expected retention of chlorides. This finding does not support the concept of an inhibition of glu-coneogenesis by testosterone.