Excretion of 14C‐edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus
Open Access
- 1 March 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 44 (3), 534-543
- https://doi.org/10.1111/j.1476-5381.1972.tb07290.x
Abstract
1 The metabolism and biliary excretion of 14C-edrophonium chloride was studied in Wistar rats. 2 Approximately 5% of the dose was recovered from bile in 6 hours. Most of the radioactivity was eliminated as 14C-edrophonium glucuronide. Small amounts of the unchanged drug were also detected in bile, particularly during the first hour after administration of the drug. 3 The concentration of 14C-edrophonium glucuronide in bile was approximately 15–20 times its concentration in plasma. 4 In contrast, the concentration of unchanged 14C-edrophonium was similar in bile and plasma. 5 Evidence is presented that unchanged 14C-edrophonium is transferred from plasma to bile via the peribiliary vascular plexus.Keywords
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