Sporulation and the Production of Serine Protease and Cephamycin C by Streptomyces lactamdurans
- 1 April 1979
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 15 (4), 522-526
- https://doi.org/10.1128/aac.15.4.522
Abstract
Streptomyces lactamdurans, producer of the antibiotic cephamycin C, excretes at least two proteases. Physiological studies indicate that antibiotic synthesis and serine protease formation are coordinately regulated. Both are produced only after culture growth ends, and they appear with essentially identical kinetics. In addition, strains which produce superior levels of cephamycin C form equally superior levels of the serine protease. Genetic evidence reveals that the syntheses of the antibiotic and serine proteases are associated with sporulation. Mutants which fail to produce aerial hyphae (bald mutants) also fail to synthesize the antibiotic and serine proteases.This publication has 5 references indexed in Scilit:
- The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions.1977
- Cephamycins, a New Family of β-Lactam Antibiotics: Antibacterial Activity and Resistance to β-Lactamase DegradationAntimicrobial Agents and Chemotherapy, 1973
- Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. nAntimicrobial Agents and Chemotherapy, 1972
- Characterization of Proteinases Excreted by Bacillus subtilis Marburg Strain during SporulationJournal of Applied Bacteriology, 1970
- Sporulation and the production of antibiotics, exoenzymes, and exotonins.1969