Acetylation of 5-aminosalicylate by hamster colon arylamineN-acetyltransferase
- 1 February 1990
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 10 (1), 73-74
- https://doi.org/10.1002/jat.2550100114
Abstract
Recent evidence suggests that 5‐aminosalicylate acts as an anti‐inflammatory agent by virtue of its ability to act as a free‐radical scavenger. The major metabolite, N‐acetyl‐5‐aminosalicylate is not an effective free‐radical scavenger. We have demonstrated that an arylamine N‐acetyltransferase from hamster colon can directly acetylate 5‐aminosalicylate, suggesting that the colon may have the ability to modulate the activity of this agent through metabolic inactivation.This publication has 8 references indexed in Scilit:
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