Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations.
- 1 June 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (6), 2969-2971
- https://doi.org/10.1073/pnas.75.6.2969
Abstract
Cell fusion was induced by [human and mammalian] brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection system, standardized against fusion induced by Sendai virus. Correlation between the logarithm of virus dilution and the hybrid colony number gave similar curves for scrapie virus and Sendai virus. Fusion induction may explain some aspects of pathogenesis in these diseases and provide a potential in vitro assay. [Mouse cells were used.].This publication has 18 references indexed in Scilit:
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