THE EFFECT OF ADRENOCORTICOTROPHIC HORMONE ON THE URINARY EXCRETION OF SODIUM, CHLORIDE, POTASSIUM, NITROGEN AND GLUCOSE IN NORMAL RATS

Abstract

THE PRODUCTION of glycosuria and hyperglycemia in normal forcefed rats by the administration of large amounts of either 17-hydroxycorticosterone or of 17-hydroxy-ll-dehydrocorticosterone has been reported (Ingle, Sheppard, Evans and Kuizenga, 1945). In the present study it was shown that the administration of pure adrenocorticotrophic hormone to similar rats force-fed a high carbohydrate diet also caused glycosuria and hyperglycemia, with an accompanying increase in the excretion of nitrogen and potassium and inhibition of growth. It was not established that the hormone had any direct effect on the excretion of sodium and chloride. Some of the data relative to production of glycosuria have been the subject of a preliminary report (Ingle, Winter, Li and Evans, 1945).