Chromosome changes in a patient achieving complete remission in the acute phase of chronic myelogenous leukemia
- 1 April 1979
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 6 (2), 155-161
- https://doi.org/10.1002/ajh.2830060208
Abstract
A patient with chronic myelogenous leukemia (CML) had a Philadelphia chromosome (Ph′) [t(9q+;22q–)] in all cells and trisomy C in 13% of cells (later determined to be trisomy 8) at the time of diagnosis. After 21 months of intermittent treatment with busulfan, the acute phase developed with the appearance of an additional abnormality (trisomy ?19). During a complete remission and reconversion to the chronic phase, trisomies 8 and ?19 disappeared, although the Ph′ remained. Following a period of marked thrombocytosis, a second relapse occurred with the reappearance of both marker chromosomes.Keywords
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