Effect of p H on In Vitro Phagocytosis of Streptococcus pyogenes

Abstract

Phagocytosis experiments were performed with mouse peritoneal leucocytes (MPL). The natural p H of the mouse peritoneal cavity was found to be between 6.1 and 6.3. The phagocytic and intracellular killing activities of MPL by p H variations was studied. It was observed that the optimal ingestion and intracellular killing of bacteria is at the natural p H of the peritoneal cavity.