Inheritance of the macrophage alloantigenic marker (Mph-1) in inbred mice

Abstract

SUMMARY: Improvements in cytotoxic technique allowed a determination to be made of the strain distribution and inheritance of Mph-1, the mouse peritoneal exudate cell alloantigen. Mph-l^b, the allele in B10 lines, is inherited as a Mendelian co-dominant gene. In a 3-point backcross using the colour markers pink eye dilution (p) and chinchilla (c^ch) it was shown to map about 36 units from p in the order p-c^ch-Mph-l on chromosome 7. An alternative antigen, Mph-1.1, has been identified on strains F/St and I/StDa.