Potentially carcinogenic analogues of the carcinogen hexamethylphosphoramide: evaluation in vitro
Open Access
- 1 September 1978
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 38 (3), 418-427
- https://doi.org/10.1038/bjc.1978.223
Abstract
Experiments conducted in vitro are described which indicate that a family of specifically substituted phosphoramides may share the carcinogenic properties displayed by the structurally novel carcinogen, hexamethylphosphoramide (HMPA). Most of the analogues tested only gave a positive response in vitro when using a substantially modified liver homogenate activation system (S-9 mix). The analogy drawn in our earlier paper between this new class of potential carcinogens and the nitrosamine carcinogens, has been strengthened. The following compounds gave a positive response in the cell transformation assay of Styles: hexamethylphosphoramide (HMPA), hexamethylphosphorous triamide, hexamethylphosphorothioic triamide, tripiperidinophosphine oxide, phosphorothioic trimorpholide and diethoxymorpholinophosphine oxide (DEMPA).Keywords
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