Resolution of Lipid-Containing Atherosclerotic Lesions Induced by Injury
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 14 (4), 193-203
- https://doi.org/10.1159/000158128
Abstract
In previous experiments, injury-induced atherosclerosis has been shown to be associated with the development of fatty streaks. The findings suggested that fatty streaks might represent a stage in healing of intimal injury evolving to fibrous plaques, free of lipid. The present experiment was designed to study the incidence and evolution of these lesions during a 2-week period of lesion retrogression following removal of a catheter placed in the aorta for 1 week. The findings indicate that as fat-containing lesions, either of the thromboatherosclerotic or fatty streak varieties, decreased, the amount of nonlipid-containing fibrous lesions increased.Keywords
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