The locomotor effect of clonidine and its interaction with ?-flupenthixol or haloperidol in the developing rat
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 313 (1), 33-37
- https://doi.org/10.1007/bf00505802
Abstract
The interaction of clonidine with α-flupenthixol and haloperidol on the locomotion was investigated in the rat during postnatal development. A subcutaneous injection of clonidine 0.039–3.9 μmol/kg produced a marked hypermotility in infant animals between day 1 and day 7 but hypomotility in animals older than 20 days. Pretreatment with α-flupenthixol and haloperidol significantly reduced clonidine-hypermotility in infants. In adult rats, clonidine-hypomotility were increased by a preceding administration of α-flupenthixol. It is suggested that intact function of both α-adrenoceptors and dopamine receptors is involved in the control of locomotor activity in developing rats and that there is the complex interaction of noradrenergic and dopaminergic system in the control of locomotor activity.This publication has 21 references indexed in Scilit:
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