Effects of Prolonged Thyrocalcitonin Administration on Paget's Disease of Bone

Abstract

Three patients with an extensive and severe form of Paget's disease of bone were given porcine thyrocalcitonin every 12 hours for one month or longer. Striking reduction of alkaline phosphatase was observed in three subjects, and decreased hydroxyprolinuria in two. A 16 per cent decrease in cardiac output was measured after 17 weeks of hormone administration to one patient. Evidence of decreased bone turnover persisted for four to five weeks after withdrawal of the hormone from two subjects. Neither tetany nor rebound hypercalcemia occurred. The well tolerated suppressive effects observed suggest a role for thyrocalcitonin in the management of this disorder.