IMMUNOLOGICAL STUDIES IN ULCERATIVE COLITIS
Open Access
- 1 December 1968
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 128 (6), 1339-1352
- https://doi.org/10.1084/jem.128.6.1339
Abstract
The incidence and height of antibody titers to colon, assayed by indirect hemagglutination with a heat stable colon extract from germ free rats, is significantly higher in sera from patients with ulcerative colitis than in those from healthy controls or from patients with amebic liver abscess or dysentery. While sera from ulcerative colitis patients and controls are indistinguishable in regard to incidence and height of antibody titers to Forsman antigen, Staphylococcus aureus S 209, Clostridium difficile, and several common strains of E. coli, they have elevated titers and increased incidence of antibodies to a heat stable antigen of E. coli O14. Patients with amebic dysentery have normal titers of such antibodies.Keywords
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