EFFECT OF THE TOTAL LOSS OF PANCREATIC JUICE ON THE BLOOD AND LIVER LIPIDS

Abstract

A total pancreatic fistula was prepared in 17 normal dogs by converting the segment of duodenum receiving the pancreatic duct into a closed sac and connecting this to the exterior by means of a gold-plated cannula. These animals secreted from 500 to 2000 c.c. of pancreatic juice per day. The loss of Na and Cl ion was compensated for by the daily adm. of 1500 to 2500 c.c. of Ringer''s soln. The animals survived for 4-50 wks. They did not develop the hypo-lipemia and fatty infiltration of the liver seen in the insulin treated depancreatized dog. Lipocaic is evidently not present in pancreatic juice in any significant amt.