The effect of metallic salts on the glycolysis and respiration of tissues1

Abstract

Results for normal and malignant tissues in vitro are given, the former agreeing well with published values. Liver showed no aerobic glycolysis. Metallic salts depressed anaerobic glycolysis and respiration in the order: HgI2, HgCl2>Cu>Zn>Cd>Ca. Pb in low concentrations slightly accelerated glycolysis of malignant tissues, and in high concentrations respiration. It affected normal tissues less. Metallic poisons influenced glycolysis more in malignant than in normal tissues; their relative effects on respiration and glycolysis being reversed when the 2 tissues are compared. Inactivation of the enzyme followed the unimolecular law.