The amino acid sequence of human liver apoferritin
- 28 November 1983
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 164 (1), 139-144
- https://doi.org/10.1016/0014-5793(83)80037-4
Abstract
The protein component of the iron storage molecule, ferritin, contains 24 subunits in form of a hollow shell known as apoferritin. The amino acid sequence has been determined for apoferritin subunits from human liver. The sequence comprises 174 amino acids giving an M r of 19 900. It shows extensive homology with the primary structures of apoferritins from human and horse spleen and from rat liver. Sequence substitutions are discussed in relation to the known three-dimensional structure of horse spleen apoferritin. Evidence for a second minor sequence in human liver apoferritin is presented.Keywords
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