LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER
Open Access
- 1 June 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (6), 1406-1409
- https://doi.org/10.1084/jem.135.6.1406
Abstract
The rat liver mixed function oxidase system which is responsible for the metabolism of endogenous and exogenous compounds has been shown to be affected by lead and methyl mercury. Administration of these environmental pollutants to rats results in a decrease in cytochrome P-450 content and inhibition of in vitro N-demethylase and hydroxylase activities. The in vitro enzyme-inhibiting effects of the metals found pharmacological expression in the whole animal by prolongation of hexobarbital-induced sleeping times.Keywords
This publication has 15 references indexed in Scilit:
- Mercurialism: Environmental and Occupational AspectsAnnals of Internal Medicine, 1972
- Lead as an environmental poisonClinical Pharmacology & Therapeutics, 1971
- Lead toxicity: a problem in environmental pathology.1971
- Biphasic decrease of radioactive hemoprotein from liver microsomal carbon monoxide-binding particles. Effect of phenobarbital and chlordane.1969
- Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylationLife Sciences, 1969
- Lead poisoning as a disorder of heme synthesis.1968
- Evidence for Biochemically Different Types of Vesicles in the Hepatic Microsomal Fraction*The Journal of Biochemistry, 1966
- INHIBITION OF DRUG METABOLISM .I. KINETICS OF INHIBITION OF N-DEMETHYLATION OF ETHYLMORPHINE BY 2-DIETHYLAMINOETHYL 2,2-DIPHENYLVALERATE HCI (SKF 525-A) AND RELATED COMPOUNDS1966
- CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES .I. EVIDENCE FOR ITS HEMOPROTEIN NATURE1964
- Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of LiverJournal of Biological Chemistry, 1962