Some physiological and pharmacological characteristics of the stimulus induced release of norepinephrine from the rabbit superior cervical ganglion
- 1 January 1975
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 291 (2), 163-174
- https://doi.org/10.1007/bf00500047
Abstract
The cervical sympathetic nerve stimulated release of norepinephrine (NE) from the rabbit superior cervical ganglion (SCG) was characterized. The quantity of NE released per impulse declined with increasing stimulation frequency over the range of 3/sec to 15/sec. Nerve stimulated NE release was potentiated by 1 micromolar desmethylimipramine and 25 micromolar phenoxybenzamine and inhibited by 1 micromolar bretylium, 25 micromolar methoxamine and 1 micromolar prostaglandin E1. These results suggest that nerve stimulated NE release in the rabbit SCG occurs from sympathetic fibers which are subject to the same neuro-secretory control mechanisms as sympathetic fibers elsewhere in the autonomic nervous system.Keywords
This publication has 31 references indexed in Scilit:
- Prostaglandin Action on Noradrenaline Release and Mechanical Responses in the Stimulated Guinea Pig Vas DeferensActa Physiologica Scandinavica, 1974
- Uncompetitive Character of Inhibition by Prostaglandin E., of the Enhancing Effect of a-Adrenoceptor Blocking Drug on Noradrenaline Secretion in Isolated Guinea-Pig Vas DeferensActa Physiologica Scandinavica, 1973
- Increased Release of Noradrenaline from Stimulated Guinea Pig Vas Deferens after Indomethacin TreatmentActa Physiologica Scandinavica, 1973
- Augmented Noradrenaline Release Following Nerve Stimulation after Inhibition of Prostaglandin Synthesis with IndomethacinActa Physiologica Scandinavica, 1972
- 3H‐Noradrenaline Release and Mechanical Response in the Field Stimulated Mouse Vas DeferensActa Physiologica Scandinavica, 1971
- Potentiating Action of Desmethylimipramine on the Cardiovascular Effects of Noradrenaline and Some Other Pressor AgentsActa Physiologica Scandinavica, 1970
- Effects of desipramine, phentolamine and phenoxybenzamine on the release of noradrenaline from isolated tissuesJournal of Pharmacy and Pharmacology, 1970
- Inhibition by prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleenLife Sciences, 1969
- Quantitative in Vitro Studies on Noradrenaline Uptake and its Inhibition by Amphetamine, Desipramine and ChlorpromazineActa Physiologica Scandinavica, 1967
- Impulse Frequency in Sympathetic Vasomotor Fibres Correlated to the Release and Elimination of the TransmitterActa Physiologica Scandinavica, 1952