Recurrent Salmonella Bacteremia in Interleukin-12 Receptor β1 Deficiency
Open Access
- 10 March 2006
- journal article
- case report
- Published by Oxford University Press (OUP) in Journal of Tropical Pediatrics
- Vol. 52 (4), 296-298
- https://doi.org/10.1093/tropej/fml001
Abstract
Interleukin-12 receptor β1 (IL12RB1) deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.Keywords
This publication has 9 references indexed in Scilit:
- Interleukin-12 Receptor 1 Chain Deficiency in a Child with Disseminated TuberculosisClinical Infectious Diseases, 2005
- Clinical Tuberculosis in 2 of 3 Siblings with Interleukin-12 Receptor 1 DeficiencyClinical Infectious Diseases, 2003
- Interleukin-12 Receptor β1 Deficiency Presenting as Recurrent Salmonella InfectionClinical Infectious Diseases, 2003
- Inherited Interleukin-12 Deficiency: IL12B Genotype and Clinical Phenotype of 13 Patients from Six KindredsAmerican Journal of Human Genetics, 2002
- Interleukin‐12 Receptor β1 Deficiency in a Patient with Abdominal TuberculosisThe Journal of Infectious Diseases, 2001
- High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor DeficiencyPediatrics, 2001
- Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1)The Journal of Experimental Medicine, 2000
- A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infectionNature Genetics, 1999
- Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor DeficiencyScience, 1998