T-LYMPHOCYTE RECOGNITION OF ALLOANTIGEN INVITRO .1. SIGNIFICANCE OF FC-RECEPTOR-POSITIVE T AND B STIMULATOR CELLS IN GENERATION OF CYTOTOXIC-T-LYMPHOCYTES

Abstract

This article reports attempts to characterize the potent stimulator cell(s) that induce Fc receptor (FcR)-negative T [thymus-derived] lymphocytes to differentiate into cytotoxic T lymphocytes in vitro. Two categories of such cells were found: resting B [bone marrow-derived] cells, FcR+ T cells and macrophages; and T cells activated in 800-R-irradiated mice against H-2 antigens or M-locus antigens or activated in vitro by concanavalin A. The distinction between potent and weak stimulator cells is discussed in relation to the surface antigenic markers and the immunological function of these cells.