FAILURE OF THE DINITROPHENOL-INDUCED FALL IN PLASMA PROTEIN-BOUND IODINE TO STIMULATE AUGMENTED TSH PRODUCTION1

Abstract

THE fall in circulating protein-bound iodine induced by thyroidectomy or by antithyroid agents results in hypertrophy and hyperplasia of anterior pituitary basophils, and this is presumed to reflect increased TSH production. That this is not an invariable result, however, is brought out in the present study with dinitrophenol (DNP). DNP administration depresses the concentration of protein-bound iodine in plasma of the rat, but affects neither the anterior pituitary basophils nor the size and histological structure of the thyroid gland.