THE EFFECTS OF ULTRAVIOLET-IRRADIATED POLYURIDYLIC ACID IN CELL-FREE PROTEIN SYNTHESIS IN ESCHERICHIA COLI, II. THE INFLUENCE OF SPECIFIC PHOTOPRODUCTS
- 1 October 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (4), 657-664
- https://doi.org/10.1073/pnas.50.4.657
Abstract
Two uracil photoproducts are formed when polyuridylic-acid (poly-U) is irradiated with ultraviolet light. A molecule of water may be added at the 4, -5 double bond of the uracil moieties as a result of irradiation which can be reconverted to uracil by base-catalyzed dehydration. The other photoproduct formed is a uracil-uracil dimer which reverts to uracil by reirradiation at lower wavelengths of ultra-violet light. The water adduct is responsible for the coding transition of C14-phenylalanine to C14-serine, and the formation of dimer results in the loss of the incorporation of C14-phenylalanine which is not replaced by any other amino-acid.Keywords
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