Passive Transfer of Local Cutaneous Hypersensitivity to Tuberculin

Abstract

The method of local passive sensitization so extensively employed in human allergy (Prausnitz-Küstner reaction) and in experimental anaphylaxis (Opie and others), can also be applied to the cellular transfer of tuberculin hypersensitivity discovered by Chase.³ Compared with the latter's experimental procedure, this method offers the advantage of considerably reducing the number of cell donors necessary for successful transfer. The technic used is, however, susceptible of improvement, as in the presence of a marked primary reaction of cavy skin to the injection of homologous exudate cells none but fairly strong tuberculin reactions can be recorded with confidence.