The balance of pyridine nucleotides and ATP in adipose tissue.

Abstract

In-vitro studies with rat adipose tissue indicate an almost equivalent balance between formation and utilization of reduced pyridine nucleotides in the cytoplasm. Estimations of the metaoolism of adenosine triphosphate (ATP) indicate that requirements for known synthetic reactions account for the majority of the ATP produced in the presence of insulin. In the presence of lipolytic hormones, the amount of ATP which could be generated is nearly twice that required for synthetic reactions, suggesting extensive uncoupling.