In July, 1923, McClure and Aldrich1published a preliminary report of their observations on the time required for disappearance of intradermally injected salt solution. They determined that: If 0.2 c.c. of an 0.8 per cent. aqueous solution of sodium chlorid is injected intracutaneously in a normal child, a circumscribed snow-white elevation, in which the pores are accentuated, is immediately produced at the point of the injection. Although the extreme whiteness disappears in from one half to one minute, the elevation persists for a considerable time. In normal children, the time required for complete disappearance of the wheal as determined by palpation was fifty minutes or more. In children with edema, there was a much more rapid disappearance of the wheal, the time being in some instances a minute or less. They concluded: The results so far obtained suggest that this test may be of value; first, in the detection