Stimulation of food intake in the rabbit and rat by inhibition of glucose metabolism with 2-deoxy-d-glucose.

Abstract

Studied 8 mature new zealand rabbits and 4 young white rats under 2 feeding patterns. If fed daily only during a 6-hr test period, 2-deoxy-d-glucose (2-dg) injected subcutaneously had no consistent effect on food intake. However, if fed ad lib 24 hr/day, 2-dg injected subcutaneously or ip stimulated food intake (up to 1.9 times) during a 6-hr test period. On the latter feeding pattern, glucose injected ip depressed food intake. Results support the hypothesis that availability of glucose for tissue metabolism is part of the control system for food intake in these species. (PsycINFO Database Record (c) 2006 APA, all rights reserved)