Benign chronic bullous dermatosis of childhood. Linear IgA and C3 deposition on the basement membrane

Abstract

Benign chronic bullous dermatosis of childhood (BCBDC) is characterized by predominantly monomorphous, large, tense bullae with a predilection for the lower part of the trunk, the pelvic region and the lower extremities. Most patients have blisters for 2-3 yr and experience spontaneous exacerbations and remissions. This is apparently the first known case in which a linear band of IgA [immunoglobulin A] (but no IgG or IgM) and complement were found at the epidermal basal lamina, as demonstrated by immunofluorescence studies.