Cortisol Secretion in Relation to Age in Major Depression1

Abstract

Unmedicated hospitalized patients (25), ages 26-64, with severe major depressive disorders, endogenous subtype, were evaluated both clinically and endocrinologically. Although measures reflecting cortisol secretion did not correlate with symptom dimensions and diagnostic subtypes, a significant relationship was found between cortisol secretion and age during endogenous depressive illness; this included the mean 24 h plasma cortisol, assessed by sampling every 30 min for 24 h, as well as other single plasma cortisol assessments on other days. After clinical recovery, when plasma cortisol levels returned to normal, there was no significant relationship between cortisol secretion and age. Replication is required of this apparent interaction among age, depressive illness and cortisol secretion. The results may relate to the proposed role of brain noradrenaline [norepinephrine] in tonically inhibiting cortisol secretion, the decline of hypothalamic noradrenaline with age and the hypothesized deficit in depressive illness.