Laryngeal Carcinoma IV. Analysis of treatment results using the Cohen model

Abstract

Long-term results obtained in the irradiation treatment of 308 patients with laryngeal carcinoma are analyzed with respect to local recurrence and complications. In this analysis the Cell Population Kinetic model proposed by COHEN is used. The model for squamous cell carcinoma is useful and in close agreement with observations of local recurrence, although a slight modification may be justified from the present data. No special model exists for late edema; the model for late effects in the vascular stroma seems to be useful in this respect. Based on the model, a working hypothesis was proposed by which it is possible to predict the frequency of local recurrence and late edema. An optimum treatment schedule is calculated and converted to a split-course technique.