A method for the evaluation of the local antiandrogenic action of 5α-reductase inhibitors on human skin
- 31 May 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 102 (6), 695-701
- https://doi.org/10.1111/j.1365-2133.1980.tb06571.x
Abstract
A method was developed for the 1st time that allows the evaluation of the effect of therapeutic concentrations of 5.alpha.-reductase inhibitors [progesterone] in human skin without applying radioactivity to the skin. The method makes it possible to determine whether inhibition is found only at the application site or in other parts of the skin.This publication has 7 references indexed in Scilit:
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- The effect of topically applied progesterone on sebum excretion rateBritish Journal of Dermatology, 1979
- The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1Endocrinology, 1973
- TheIn VivoandIn VitroConversion of Testosterone to 17β-Hydroxy-5α-Androstan-3-One (Dihydrotestosterone) by the Sebaceous Gland of HamstersEndocrinology, 1972
- Differential Rates of Conversion of Testerone to Dihydrotestosterone In Acne and in Normal Human Skin- a Possible Pathogenic Factor in AcneJournal of Investigative Dermatology, 1971