The Relation of Epilepsy to Auto-intoxication.—C. Agostini (Rivista Sperimentale di Freniatria, 1896, pp. 267 and 435), following up the researches of Voisin and of Mirto, who have shown that the urine of epileptics possesses a special toxicity, and those of a number of other observers who have demonstrated that true epileptic fits can be produced as the result of auto-intoxication by abnormal products developed in the gastro-intestinal canal, has made an investigation into the composition and toxicity of the gastric fluid and urine in a number of cases of epileptic insanity at various periods in relation to their fits. The great care and strict attention to scientific requirements with which he appears to have carried out this difficult research, are such as to inspire confidence in the accuracy of the results he has obtained, as well as of the conclusions he has deduced from them. Without overturning any long-accepted theories he has made what certainly appears to be a most important contribution to our knowledge of the pathogenesis of epilepsy, and he has formulated new principles of treatment which, while they seem in the light of his investigations to be eminently rational, have already, as carried out by himself at least, been followed with success of a very remarkable and promising kind.