Primary Structure of Neocarzinostatin, an Antitumor Protein
- 24 November 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4063), 875-876
- https://doi.org/10.1126/science.178.4063.875
Abstract
The antitumor protein neocarzinostatin is an acidic single-chain molecule, cross-linked by two disulfide bridges, and consists of 109 amino acid residues. Complete disulfide bond reduction and S-carboxymethylation was achieved in liquid ammonia. Sequence determination of five tryptic fragments led to the proposed primary structure.Keywords
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