Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis

Abstract

A basic, extractable, indolic type of compound, which was derivatized with heptafluorobutyric anhydride and pyridine, was obtained from the CSF of patients with acute tuberculous meningitis. The compound was detected by fruquency-pulsed, modulated electron catre GLC, and it was tentatively identified by mass spectrometry as 3-(2''-ketohexyl)indoline. The compound was valuable for differentiating between tuberculous, cryptococcal and aseptic [viral] meningitides.