Effect of Chlorpromazine on Serum Growth-Hormone Concentration in Man

Abstract

Chlorpromazine, a commonly used tranquilizer of the phenothiazine group, was administered orally to 15 subjects in doses of 25 mg four times a day for one week. Fasting serum growth-hormone concentrations and growth-hormone responses to insulin stimulation were measured before and after the treatment period. Definite suppressive effects were found: fasting levels were decreased in 10 of 15 patients. At one and two hours after intravenous insulin injection the levels were lower in 13 of 14, and 10 of 15 subjects, respectively. The decrease was statistically significant during fasting (p<0.05), at one hour (p<0.005) and at two hours (p<0.05).