Total synthesis of (−)-spirangien A and its methyl ester
- 6 November 2008
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 47,p. 6408-6410
- https://doi.org/10.1039/b816229h
Abstract
The first total synthesis of (−)-spirangien A, a cytotoxic and antifungal polyketide of myxobacterial origin, is reported; this exploits a Stork–Wittig olefination and double Stille cross-coupling sequence to install the sensitive pentaene side chain onto a fully elaborated spiroacetal core, leading initially to the methylester of spirangien A.Keywords
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