Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens
- 9 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4615), 1082-1084
- https://doi.org/10.1126/science.6308771
Abstract
The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.This publication has 30 references indexed in Scilit:
- Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinantsNature, 1982
- Simultaneous Separation and Purification of Neurofilament and Glial Filament Proteins from BrainJournal of Neurochemistry, 1981
- Immunochemical Characterization of Antisera to Rat Neurofilament SubunitsJournal of Neurochemistry, 1981
- Antibodies to neurofilament, glial filament, and fibroblast intermediate filament proteins bind to different cell types of the nervous system.The Journal of cell biology, 1981
- Studies on the biosynthesis of neurofilament proteins.The Journal of cell biology, 1980
- Intermediate Filaments from Bovine, Rat, and Human CNS: Mapping Analysis of the Major ProteinsJournal of Neurochemistry, 1980
- Intermediate filaments in nervous tissuesThe Journal of cell biology, 1978
- Slow Axonal Transport of Neurofilament Proteins: Impairment of β,β′-Iminodipropionitrile AdministrationScience, 1978
- Ultrastructural observations in ParkinsonismThe Journal of Pathology, 1969
- THE INCIDENCE AND CHARACTERISTICS OF LEWY BODIES IN IDIOPATHIC PARALYSIS AGITANS (PARKINSON'S DISEASE)Journal of Neurology, Neurosurgery & Psychiatry, 1960