Attempts to Demonstrate Interference Between Coxsackie and Poliomyelitis Viruses in Mice and Monkeys

Abstract

The intracerebral inoculation of mixtures of viruses into adult mice indicates that a group A Coxsackie virus decreases the incubation period of the MEF1 strain of poliomyelitis, while a group B Caxsackie virus increases the incubation time. Similar effects could not be demonstrated in monkeys using a strain of poliomyelitis recently isolated from the cord of a fatal human case. Attention was drawn to peculiarities in the time of onset of paralysis with mice infected with the MEF1 strain of poliomyelitis.