Transforming potential of a human protooncogene (c-fps/fes) locus.
- 1 May 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (10), 3039-3043
- https://doi.org/10.1073/pnas.81.10.3039
Abstract
The protooncogene c-fps/fes is a single vertebrate locus homologous to both the fps transforming gene of Fujinami avian sarcoma virus and the fes transforming gene of 2 feline sarcoma virus isolates. The human c-fps/fes locus was previously cloned and characterized. A recombinant gene in which 3'' human c-fps/fes sequences replace over 80% of the feline sacroma virus fes sequences transforms NIH 3T3 mouse fibroblasts and encodes a protein kinase. Cells transformed by this recombinant possess incresed phosphotyrosine levels. A large carboxyl portion of a human c-fps/fes protein product can functionally complement a retroviral transforming protein.This publication has 29 references indexed in Scilit:
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